Polyamine depletion induces G<sub>1 </sub>and S phase arrest in human retinoblastoma Y79 cells
<p>Abstract</p> <p>Background</p> <p>Polyamines and ornithine decarboxylase (ODC) are essential for cell proliferation. DL-α-difluoromethylornithine (DFMO), a synthetic inhibitor of ODC, induces G<sub>1 </sub>arrest through dephosphorylation of retinoblastom...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2008-01-01
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| Series: | Cancer Cell International |
| Online Access: | http://www.cancerci.com/content/8/1/2 |