A Homozygous Loss-of-Function Mutation in <i>MSH5 </i>Abolishes MutSγ Axial Loading and Causes Meiotic Arrest in NOA-Affected Individuals

A Homozygous Loss-of-Function Mutation in <i>MSH5 </i>Abolishes MutSγ Axial Loading and Causes Meiotic Arrest in NOA-Affected Individuals

Non-obstructive azoospermia (NOA), characterized by spermatogenesis failure and the absence of sperm in ejaculation, is the most severe form of male infertility. However, the etiology and pathology between meiosis-associated monogenic alterations and human NOA remain largely unknown. A homozygous &l...

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Bibliographic Details
Main Authors: Chenjia Gong, Tanveer Abbas, Zubair Muhammad, Jianteng Zhou, Ranjha Khan, Hui Ma, Huan Zhang, Qinghua Shi, Baolu Shi
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:International Journal of Molecular Sciences
Subjects:
male infertility
non-obstructive azoospermia
meiotic arrest
recombination
synapsis
<i>MSH5</i>
Online Access:https://www.mdpi.com/1422-0067/23/12/6522

Internet

https://www.mdpi.com/1422-0067/23/12/6522

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