Complex Mitochondrial Dysfunction Induced by TPP<sup>+</sup>-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

Complex Mitochondrial Dysfunction Induced by TPP<sup>+</sup>-Gentisic Acid and Mitochondrial Translation Inhibition by Doxycycline Evokes Synergistic Lethality in Breast Cancer Cells

The mitochondrion has emerged as a promising therapeutic target for novel cancer treatments because of its essential role in tumorigenesis and resistance to chemotherapy. Previously, we described a natural compound, 10-((2,5-dihydroxybenzoyl)oxy)decyl) triphenylphosphonium bromide (GA-TPP<sup>...

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Bibliographic Details
Main Authors: Sebastián Fuentes-Retamal, Cristian Sandoval-Acuña, Liliana Peredo-Silva, Daniela Guzmán-Rivera, Mario Pavani, Natalia Torrealba, Jaroslav Truksa, Vicente Castro-Castillo, Mabel Catalán, Ulrike Kemmerling, Félix A. Urra, Jorge Ferreira
Format: Article
Language:English
Published: MDPI AG 2020-02-01
Series:Cells
Subjects:
inhibition of the electron transport chain
inhibition of alpha-ketoglutarate dehydrogenase complex
mitochondrially targeted
decyl polyhydroxybenzoate triphenylphosphonium derivatives
doxycycline
mitochondrial ribosome inhibition
Online Access:https://www.mdpi.com/2073-4409/9/2/407

Internet

https://www.mdpi.com/2073-4409/9/2/407

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