The Ameliorative Effect of Empagliflozin in Vigabatrin-Induced Cerebellar/Neurobehavioral Deficits: Targeting mTOR/AMPK/SIRT-1 Signaling Pathways

The Ameliorative Effect of Empagliflozin in Vigabatrin-Induced Cerebellar/Neurobehavioral Deficits: Targeting mTOR/AMPK/SIRT-1 Signaling Pathways

<b>Introduction.</b> Vigabatrin (VGB) is an antiepileptic drug that acts to irreversibly inhibit the γ-aminobutyric acid (GABA) transaminase enzyme, elevating GABA levels. Broad studies have established that long-term treatment and/or high doses of VGB lead to variable visual defects. Ho...

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Bibliographic Details
Main Authors: Rabab M. Amer, Amira Kamel Eltokhy, Rasha Osama Elesawy, Amany Nagy Barakat, Eman Basha, Omnia Safwat Eldeeb, Alshimaa Aboalsoud, Nancy Mohamed Elgharabawy, Radwa Ismail
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Molecules
Subjects:
vigabatrin
empagliflozin
GFAP
mTOR
AMPK
SIRT-1
Online Access:https://www.mdpi.com/1420-3049/27/12/3659

Internet

https://www.mdpi.com/1420-3049/27/12/3659

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