Cyclophosphamide and epirubicin induce high apoptosis in microglia cells while epirubicin provokes DNA damage and microglial activation at sub-lethal concentrations

Cyclophosphamide and epirubicin induce high apoptosis in microglia cells while epirubicin provokes DNA damage and microglial activation at sub-lethal concentrations

Chemotherapy Related Cognitive Impairment (CRCI), also called chemobrain, diminishes cancer patient’s life quality. Breast cancer (BC) patients have been described to be importantly affected, however, the mechanism leading to CRCI has not been fully elucidated. Recent research proposes microglia as...

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Bibliographic Details
Main Authors: Rafael de la Hoz-Camacho, Ana Luisa Rivera-Lazarin, Jose Manuel Vazquez-Guillen, Diana Caballero-Hernandez, Edgar Mendoza-Gamboa, Ana Carolina Martinez-Torres, Cristina Rodriguez-Padilla
Format: Article
Language:English
Published: IfADo - Leibniz Research Centre for Working Environment and Human Factors, Dortmund 2022-01-01
Series:EXCLI Journal : Experimental and Clinical Sciences
Subjects:
microglia
breast cancer
neurotoxicity
chemotherapy
chemobrain
apoptosis
Online Access:https://www.excli.de/index.php/excli/article/view/4160

Internet

https://www.excli.de/index.php/excli/article/view/4160

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