ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses

ORAI1 and ORAI3 in Breast Cancer Molecular Subtypes and the Identification of ORAI3 as a Hypoxia Sensitive Gene and a Regulator of Hypoxia Responses

The remodeling of specific calcium-permeable ion channels is a feature of some breast cancer subtypes. ORAI1 is a protein that forms a calcium-permeable ion channel responsible for store-operated calcium entry (SOCE) in a variety of cell types. ORAI3, a related isoform, is not a regulator of SOCE in...

Full description

Bibliographic Details
Main Authors: Iman Azimi, Michael J.G. Milevskiy, Silke B. Chalmers, Kunsala T.D.S. Yapa, Mélanie Robitaille, Christopher Henry, Gregory J. Baillie, Erik W. Thompson, Sarah J. Roberts-Thomson, Gregory R. Monteith
Format: Article
Language:English
Published: MDPI AG 2019-02-01
Series:Cancers
Subjects:
ORAI3
ORAI1
Calcium signaling
hypoxia
breast cancer
Online Access:https://www.mdpi.com/2072-6694/11/2/208

Internet

https://www.mdpi.com/2072-6694/11/2/208

Similar Items