2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid and -benzamide: structural characterization of two precursors for antitubercular benzothiazinones

2-Chloro-3-nitro-5-(trifluoromethyl)benzoic acid and -benzamide: structural characterization of two precursors for antitubercular benzothiazinones

8-Nitro-1,3-benzothiazin-4-ones are a promising class of new antitubercular agents, two candidates of which, namely BTZ043 and PBTZ169 (INN: macozinone), have reached clinical trials. The crystal and molecular structures of two synthetic precursors, 2-chloro-3-nitro-5-(trifluoromethyl)benzoic acid,...

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Bibliographic Details
Main Authors: Adrian Richter, Richard Goddard, Tom Schlegel, Peter Imming, Rüdiger W. Seidel
Format: Article
Language:English
Published: International Union of Crystallography 2021-02-01
Series:Acta Crystallographica Section E: Crystallographic Communications
Subjects:
benzothiazinones
btz043
pbtz169
nitrobenzoic acids
nitrobenzamides
antituberculosis drugs
hydrogen bonds
crystal structure
Online Access:http://scripts.iucr.org/cgi-bin/paper?S2056989021000517

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http://scripts.iucr.org/cgi-bin/paper?S2056989021000517

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