MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes

MLKL-mediated necroptosis is a target for cardiac protection in mouse models of type-1 diabetes

Abstract Background Cardiomyocyte death contributes to cardiac pathology of diabetes. Studies have shown that the RIPK3/MLKL necroptosis signaling is activated in diabetic hearts. Deletion of RIPK3 was reported to attenuate myocardial injury and heart dysfunction in streptozocin (STZ)-induced diabet...

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Bibliographic Details
Main Authors: Ting Cao, Rui Ni, Weimin Ding, Xiaoyun Ji, Lan Li, Guangneng Liao, Yanrong Lu, Guo-Chang Fan, Zhuxu Zhang, Tianqing Peng
Format: Article
Language:English
Published: BMC 2022-08-01
Series:Cardiovascular Diabetology
Subjects:
MLKL
RIPK3
Necroptosis
Cardiomyocytes
Diabetes
Heart
Online Access:https://doi.org/10.1186/s12933-022-01602-9

Internet

https://doi.org/10.1186/s12933-022-01602-9

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