Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats

Selective Involvement of a Subset of Spinal Dorsal Horn Neurons Operated by a Prodynorphin Promoter in Aβ Fiber-Mediated Neuropathic Allodynia-Like Behavioral Responses in Rats

Mechanical allodynia (pain produced by innocuous stimuli such as touch) is the main symptom of neuropathic pain. Its underlying mechanism remains to be elucidated, but peripheral nerve injury (PNI)-induced malfunction of neuronal circuits in the central nervous system, including the spinal dorsal ho...

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Bibliographic Details
Main Authors: Tadayuki Ishibashi, Yu Yoshikawa, Daichi Sueto, Ryoichi Tashima, Hidetoshi Tozaki-Saitoh, Keisuke Koga, Ken Yamaura, Makoto Tsuda
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Molecular Neuroscience
Subjects:
neuropathic mechanical allodynia
spinal dorsal horn
inhibitory neurons
primary afferent Aβ fibers
rat
Online Access:https://www.frontiersin.org/articles/10.3389/fnmol.2022.911122/full

Internet

https://www.frontiersin.org/articles/10.3389/fnmol.2022.911122/full

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