Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver

Generation of immunodeficient pig with hereditary tyrosinemia type 1 and their preliminary application for humanized liver

Abstract Background Mice with humanized livers are important models to study drug toxicology testing, development of hepatitis virus treatments, and hepatocyte transplantation therapy. However, the huge difference between mouse and human in size and anatomy limited the application of humanized mice...

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Main Authors: Jilong Ren, Dawei Yu, Jing Wang, Kai Xu, Yanan Xu, Renren Sun, Peipei An, Chongyang Li, Guihai Feng, Ying Zhang, Xiangpeng Dai, Hongye Zhao, Zhengzhu Wang, Zhiqiang Han, Haibo Zhu, Yuchun Ding, Xiaoyan You, Xueqin Liu, Meng Wu, Lin Luo, Ziyi Li, Yong-Guang Yang, Zheng Hu, Hong-jiang Wei, Liangpeng Ge, Tang Hai, Wei Li
Format: Article
Language:English
Published: BMC 2022-03-01
Series:Cell & Bioscience
Subjects:
Liver regeneration
Immunodeficiency
Gene editing
Disease model
Online Access:https://doi.org/10.1186/s13578-022-00760-3

Internet

https://doi.org/10.1186/s13578-022-00760-3

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