Prime-boost vaccination with SA-4-1BBL costimulatory molecule and survivin eradicates lung carcinoma in CD8+ T and NK cell dependent manner.

Prime-boost vaccination with SA-4-1BBL costimulatory molecule and survivin eradicates lung carcinoma in CD8+ T and NK cell dependent manner.

Subunit vaccines containing universal tumor associated antigens (TAAs) present an attractive treatment modality for cancer primarily due to their safety and potential to generate long-term immunological responses that can safeguard against recurrences. However, TAA-based subunit vaccines require pot...

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Bibliographic Details
Main Authors: Abhishek K Srivastava, Rajesh K Sharma, Esma S Yolcu, Vahap Ulker, Kathryn MacLeod, Gunes Dinc, Haval Shirwan
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3493554?pdf=render

Internet

http://europepmc.org/articles/PMC3493554?pdf=render

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