Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts

Profound DNA methylomic differences between single- and multi-fraction alpha irradiations of lung fibroblasts

Abstract Background Alpha (α)-radiation is a ubiquitous environmental agent with epigenotoxic effects. Human exposure to α-radiation at potentially harmful levels can occur repetitively over the long term via inhalation of naturally occurring radon gas that accumulates in enclosed spaces, or as a re...

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Bibliographic Details
Main Authors: Marilyn N. Vera-Chang, John M. Danforth, Marilyne Stuart, Aaron A. Goodarzi, Marjorie Brand, Richard B. Richardson
Format: Article
Language:English
Published: BMC 2023-10-01
Series:Clinical Epigenetics
Subjects:
Alpha particles
Radon
Lung
Methylome
Aging
Cancer
Online Access:https://doi.org/10.1186/s13148-023-01564-z

Internet

https://doi.org/10.1186/s13148-023-01564-z

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