Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy

Pathological Mechanisms of Bortezomib-Induced Peripheral Neuropathy

Bortezomib, a first-generation proteasome inhibitor widely used in chemotherapy for hematologic malignancy, has effective anti-cancer activity but often causes severe peripheral neuropathy. Although bortezomib-induced peripheral neuropathy (BIPN) is a dose-limiting toxicity, there are no recommended...

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Bibliographic Details
Main Authors: Shota Yamamoto, Nobuaki Egashira
Format: Article
Language:English
Published: MDPI AG 2021-01-01
Series:International Journal of Molecular Sciences
Subjects:
bortezomib
peripheral neuropathy
neurotoxicity
neuropathic pain
drug repositioning
drug repurposing
Online Access:https://www.mdpi.com/1422-0067/22/2/888

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https://www.mdpi.com/1422-0067/22/2/888

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