Fenofibrate reduces cisplatin-induced apoptosis by inhibiting the p53/Puma/Caspase-9 pathway and the MAPK/Caspase-8 pathway rather than by promoting autophagy in murine renal proximal tubular cells

Fenofibrate reduces cisplatin-induced apoptosis by inhibiting the p53/Puma/Caspase-9 pathway and the MAPK/Caspase-8 pathway rather than by promoting autophagy in murine renal proximal tubular cells

The main lesion of cisplatin nephrotoxicity is damage to proximal tubular cells due to increased apoptosis via the mitochondrial and death receptor pathways, which may be alleviated by appropriate promotion of autophagy. Fenofibrate, a peroxisome proliferator-activated receptor-alpha (PPAR-α) activa...

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Bibliographic Details
Main Authors: Hideki Kimura, Kazuko Kamiyama, Toru Imamoto, Izumi Takeda, Shinya Masunaga, Mamiko Kobayashi, Daisuke Mikami, Naoki Takahashi, Kenji Kasuno, Takeshi Sugaya, Masayuki Iwano
Format: Article
Language:English
Published: Elsevier 2022-07-01
Series:Biochemistry and Biophysics Reports
Subjects:
Renal tubular cells
Cisplatin
Fenofibrate
Apoptosis
Mitochondrial and death receptor pathways
Autophagy
Online Access:http://www.sciencedirect.com/science/article/pii/S2405580822000371

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http://www.sciencedirect.com/science/article/pii/S2405580822000371

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