Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage

Human-lineage-specific genomic elements are associated with neurodegenerative disease and APOE transcript usage

Knowledge of genomic features specific to humans may be important for understanding disease. Here the authors demonstrate a potential role for these human-lineage-specific sequences in brain development and neurological disease.

Bibliographic Details
Main Authors: Zhongbo Chen, David Zhang, Regina H. Reynolds, Emil K. Gustavsson, Sonia García-Ruiz, Karishma D’Sa, Aine Fairbrother-Browne, Jana Vandrovcova, International Parkinson’s Disease Genomics Consortium (IPDGC), John Hardy, Henry Houlden, Sarah A. Gagliano Taliun, Juan Botía, Mina Ryten
Format: Article
Language:English
Published: Nature Portfolio 2021-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-021-22262-5

Internet

https://doi.org/10.1038/s41467-021-22262-5

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