Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts

Cyclin A1 (CCNA1) inhibits osteoporosis by suppressing transforming growth factor-beta (TGF-beta) pathway in osteoblasts

Abstract Background Osteoporosis is a genetic disease caused by the imbalance between osteoblast-led bone formation and osteoclast-induced bone resorption. However, further gene-related pathogenesis remains to be elucidated. Methods The aberrant expressed genes in osteoporosis was identified by anal...

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Bibliographic Details
Main Authors: Xiao Du, Chuanyi Zang, Qinglei Wang
Format: Article
Language:English
Published: BMC 2024-03-01
Series:BMC Musculoskeletal Disorders
Subjects:
Osteoporosis
Osteogenesis
CCNA1
TGF-beta
SMAD
Dexamethasone
Online Access:https://doi.org/10.1186/s12891-024-07303-6

Internet

https://doi.org/10.1186/s12891-024-07303-6

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