Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways

Simvastatin Enhances Activity and Trafficking of α7 Nicotinic Acetylcholine Receptor in Hippocampal Neurons Through PKC and CaMKII Signaling Pathways

Simvastatin (SV) enhances glutamate release and synaptic plasticity in hippocampal CA1 region upon activation of α7 nicotinic acetylcholine receptor (α7nAChR). In this study, we examined the effects of SV on the functional activity of α7nAChR on CA1 pyramidal cells using patch-clamp recording and ex...

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Bibliographic Details
Main Authors: Tingting Chen, Ya Wang, Tingting Zhang, Baofeng Zhang, Lei Chen, Liandong Zhao, Ling Chen
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-04-01
Series:Frontiers in Pharmacology
Subjects:
simvastatin
α7 nicotinic acetylcholine receptor (α7nAChR)
farnesyl pyrophosphate (FPP)
farnesyl transferase inhibitor (FTI)
protein kinas C (PKC)
calmodulin-kinase II (CaMKII)
Online Access:http://journal.frontiersin.org/article/10.3389/fphar.2018.00362/full

Internet

http://journal.frontiersin.org/article/10.3389/fphar.2018.00362/full

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