Cocrystal of Ibuprofen–Nicotinamide: Solid-State Characterization and In Vivo Analgesic Activity Evaluation

Cocrystal of Ibuprofen–Nicotinamide: Solid-State Characterization and In Vivo Analgesic Activity Evaluation

Ibuprofen is classified as a BCS class II drug which has low solubility and high permeability. We conducted the formation of the cocrystalline phase of ibuprofen with coformer nicotinamide to increase its solubility. The purpose of this study was to characterize the solid state of cocrystalline phas...

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Bibliographic Details
Main Authors: Yori Yuliandra, Erizal Zaini, Syofyan Syofyan, Wenny Pratiwi, Lidiya Novita Putri, Yuti Sahra Pratiwi, Helmi Arifin
Format: Article
Language:English
Published: MDPI AG 2018-06-01
Series:Scientia Pharmaceutica
Subjects:
ibuprofen
nicotinamide
cocrystalline phase
solubility
in vivo analgesic activity
writhing test
Online Access:http://www.mdpi.com/2218-0532/86/2/23

Internet

http://www.mdpi.com/2218-0532/86/2/23

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