Cocrystal of Ibuprofen–Nicotinamide: Solid-State Characterization and In Vivo Analgesic Activity Evaluation

Cocrystal of Ibuprofen–Nicotinamide: Solid-State Characterization and In Vivo Analgesic Activity Evaluation

Ibuprofen is classified as a BCS class II drug which has low solubility and high permeability. We conducted the formation of the cocrystalline phase of ibuprofen with coformer nicotinamide to increase its solubility. The purpose of this study was to characterize the solid state of cocrystalline phas...

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Dades bibliogràfiques
Autors principals: Yori Yuliandra, Erizal Zaini, Syofyan Syofyan, Wenny Pratiwi, Lidiya Novita Putri, Yuti Sahra Pratiwi, Helmi Arifin
Format: Article
Idioma:English
Publicat: MDPI AG 2018-06-01
Col·lecció:Scientia Pharmaceutica
Matèries:
ibuprofen
nicotinamide
cocrystalline phase
solubility
in vivo analgesic activity
writhing test
Accés en línia:http://www.mdpi.com/2218-0532/86/2/23

Internet

http://www.mdpi.com/2218-0532/86/2/23

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