Roxadustat, a Hypoxia-Inducible Factor 1α Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease

Roxadustat, a Hypoxia-Inducible Factor 1α Activator, Attenuates Both Long- and Short-Term Alcohol-Induced Alcoholic Liver Disease

Alcoholic liver disease (ALD) is a worldwide healthcare problem featured by inflammation, reactive oxygen species (ROS), and lipid dysregulation. Roxadustat is used for chronic kidney disease anemia treatment. As a specific inhibitor of prolyl hydroxylase, it can maintain high levels of hypoxia-indu...

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Bibliographic Details
Main Authors: Yongyao Gao, Xiaomeng Jiang, Daigang Yang, Wentong Guo, Dandan Wang, Ke Gong, Ying Peng, Hong Jiang, Cunyuan Shi, Yajun Duan, Yuanli Chen, Jihong Han, Xiaoxiao Yang
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Pharmacology
Subjects:
ALD
roxadustat
fatty liver
HIF-1α
inflammation
oxidative stress
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2022.895710/full

Internet

https://www.frontiersin.org/articles/10.3389/fphar.2022.895710/full

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