The Effect of 4-(Dimethylamino)phenyl-5-oxopyrrolidines on Breast and Pancreatic Cancer Cell Colony Formation, Migration, and Growth of Tumor Spheroids

The Effect of 4-(Dimethylamino)phenyl-5-oxopyrrolidines on Breast and Pancreatic Cancer Cell Colony Formation, Migration, and Growth of Tumor Spheroids

A series of hydrazones, azoles, and azines bearing a 4-dimethylaminophenyl-5-oxopyrrolidine scaffold was synthesized. Their cytotoxic effect against human pancreatic carcinoma Panc-1 and triple-negative breast cancer MDA-MB-231 cell lines was established by MTT assay. Pyrrolidinone derivatives <b...

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Bibliographic Details
Main Authors: Karolina Kairytė, Rita Vaickelionienė, Birutė Grybaitė, Kazimieras Anusevičius, Vytautas Mickevičius, Vilma Petrikaitė
Format: Article
Language:English
Published: MDPI AG 2024-02-01
Series:International Journal of Molecular Sciences
Subjects:
triple-negative breast cancer
pancreatic cancer
cell viability
cell migration
clonogenic assay
tumor spheroid
Online Access:https://www.mdpi.com/1422-0067/25/3/1834

Internet

https://www.mdpi.com/1422-0067/25/3/1834

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