Cross-Talk Between Histone Methyltransferases and Demethylases Regulate REST Transcription During Neurogenesis

Cross-Talk Between Histone Methyltransferases and Demethylases Regulate REST Transcription During Neurogenesis

The RE1 Silencing Transcription Factor (REST) is a major regulator of neurogenesis and brain development. Medulloblastoma (MB) is a pediatric brain cancer characterized by a blockade of neuronal specification. REST gene expression is aberrantly elevated in a subset of MBs that are driven by constitu...

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Bibliographic Details
Main Authors: Jyothishmathi Swaminathan, Shinji Maegawa, Shavali Shaik, Ajay Sharma, Javiera Bravo-Alegria, Lei Guo, Lin Xu, Arif Harmanci, Vidya Gopalakrishnan
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-05-01
Series:Frontiers in Oncology
Subjects:
REST (RE-1 silencing transcription factor)
PRC2 (Polycomb repressive complex 2)
Mll4 (KMT2D)
G9a/Glp complex
KDM7A
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2022.855167/full

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https://www.frontiersin.org/articles/10.3389/fonc.2022.855167/full

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