HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

HAPSTR1 localizes HUWE1 to the nucleus to limit stress signaling pathways

Summary: HUWE1 is a large, enigmatic HECT-domain ubiquitin ligase implicated in the regulation of diverse pathways, including DNA repair, apoptosis, and differentiation. How HUWE1 engages its structurally diverse substrates and how HUWE1 activity is regulated are unknown. Using unbiased quantitative...

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Bibliographic Details
Main Authors: Julie K. Monda, Xuezhen Ge, Moritz Hunkeler, Katherine A. Donovan, Michelle W. Ma, Cyrus Y. Jin, Marilyn Leonard, Eric S. Fischer, Eric J. Bennett
Format: Article
Language:English
Published: Elsevier 2023-05-01
Series:Cell Reports
Subjects:
CP: Molecular biology
CP: Cell biology
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124723005077

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http://www.sciencedirect.com/science/article/pii/S2211124723005077

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