Off- and on-target effects of genome editing in mouse embryos
Clustered regularly interspaced short palindromic repeats (CRISPR)-Cas-based genome editing technology has enabled manipulation of the embryonic genome. Unbiased whole genome sequencing comparing parents to progeny has revealed that the rate of Cas9-induced mutagenesis in mouse embryos is indistingu...
| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
The Society for Reproduction and Development
2018-12-01
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| Series: | The Journal of Reproduction and Development |
| Subjects: | |
| Online Access: | https://www.jstage.jst.go.jp/article/jrd/65/1/65_2018-128/_pdf/-char/en |