A novel major facilitator superfamily-type tripartite efflux system CprABC mediates resistance to polymyxins in Chryseobacterium sp. PL22-22A

A novel major facilitator superfamily-type tripartite efflux system CprABC mediates resistance to polymyxins in Chryseobacterium sp. PL22-22A

BackgroundPolymyxin B (PMB) and polymyxin E (colistin, CST) are polymyxin antibiotics, which are considered last-line therapeutic options against multidrug-resistant Gram-negative bacteria in serious infections. However, there is increasing risk of resistance to antimicrobial drugs. Effective efflux...

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Bibliographic Details
Main Authors: Lu Zhang, Miao Wang, Rui Qi, Yilin Yang, Ya Liu, Nianqing Ren, Zihan Feng, Qihao Liu, Guangxiang Cao, Gongli Zong
Format: Article
Language:English
Published: Frontiers Media S.A. 2024-02-01
Series:Frontiers in Microbiology
Subjects:
Chryseobacterium sp.
polymyxins
resistance
MFS transporter
efflux pump inhibitor
baicalin
Online Access:https://www.frontiersin.org/articles/10.3389/fmicb.2024.1346340/full

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https://www.frontiersin.org/articles/10.3389/fmicb.2024.1346340/full

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