Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model

Calcitonin gene-related peptide receptor antagonist BIBN4096BS regulates synaptic transmission in the vestibular nucleus and improves vestibular function via PKC/ERK/CREB pathway in an experimental chronic migraine rat model

Abstract Background Vestibular symptoms are frequently reported in patients with chronic migraine (CM). However, whether vestibular symptoms arise through overlapping neurobiology of migraine remains to be elucidated. The neuropeptide calcitonin gene-related peptide (CGRP) and CGRP1 receptor play im...

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Bibliographic Details
Main Authors: Ruimin Tian, Yun Zhang, Qi Pan, Yunfeng Wang, Qianwen Wen, Xiaoping Fan, Guangcheng Qin, Dunke Zhang, Lixue Chen, Yixin Zhang, Jiying Zhou
Format: Article
Language:English
Published: BMC 2022-03-01
Series:The Journal of Headache and Pain
Subjects:
CGRP
Migraine
Vestibular dysfunction
Vestibular nucleus
Central sensitization
Synaptic transmission
Online Access:https://doi.org/10.1186/s10194-022-01403-1

Internet

https://doi.org/10.1186/s10194-022-01403-1

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