Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

Adaptation to chronic ER stress enforces pancreatic β-cell plasticity

Pancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogenesis

Bibliographic Details
Main Authors: Chien-Wen Chen, Bo-Jhih Guan, Mohammed R. Alzahrani, Zhaofeng Gao, Long Gao, Syrena Bracey, Jing Wu, Cheikh A. Mbow, Raul Jobava, Leena Haataja, Ajay H. Zalavadia, Ashleigh E. Schaffer, Hugo Lee, Thomas LaFramboise, Ilya Bederman, Peter Arvan, Clayton E. Mathews, Ivan C. Gerling, Klaus H. Kaestner, Boaz Tirosh, Feyza Engin, Maria Hatzoglou
Format: Article
Language:English
Published: Nature Portfolio 2022-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-022-32425-7

Internet

https://doi.org/10.1038/s41467-022-32425-7

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