Adaptation to chronic ER stress enforces pancreatic β-cell plasticity
Pancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogenesis
| Main Authors: | , , , , , , , , , , , , , , , , , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-08-01
|
| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-32425-7 |
| _version_ | 1811320652640026624 |
|---|---|
| author | Chien-Wen Chen Bo-Jhih Guan Mohammed R. Alzahrani Zhaofeng Gao Long Gao Syrena Bracey Jing Wu Cheikh A. Mbow Raul Jobava Leena Haataja Ajay H. Zalavadia Ashleigh E. Schaffer Hugo Lee Thomas LaFramboise Ilya Bederman Peter Arvan Clayton E. Mathews Ivan C. Gerling Klaus H. Kaestner Boaz Tirosh Feyza Engin Maria Hatzoglou |
| author_facet | Chien-Wen Chen Bo-Jhih Guan Mohammed R. Alzahrani Zhaofeng Gao Long Gao Syrena Bracey Jing Wu Cheikh A. Mbow Raul Jobava Leena Haataja Ajay H. Zalavadia Ashleigh E. Schaffer Hugo Lee Thomas LaFramboise Ilya Bederman Peter Arvan Clayton E. Mathews Ivan C. Gerling Klaus H. Kaestner Boaz Tirosh Feyza Engin Maria Hatzoglou |
| author_sort | Chien-Wen Chen |
| collection | DOAJ |
| description | Pancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogenesis |
| first_indexed | 2024-04-13T13:03:15Z |
| format | Article |
| id | doaj.art-adc88863189241eabee325b0cf1b9532 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-13T13:03:15Z |
| publishDate | 2022-08-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-adc88863189241eabee325b0cf1b95322022-12-22T02:45:52ZengNature PortfolioNature Communications2041-17232022-08-0113111810.1038/s41467-022-32425-7Adaptation to chronic ER stress enforces pancreatic β-cell plasticityChien-Wen Chen0Bo-Jhih Guan1Mohammed R. Alzahrani2Zhaofeng Gao3Long Gao4Syrena Bracey5Jing Wu6Cheikh A. Mbow7Raul Jobava8Leena Haataja9Ajay H. Zalavadia10Ashleigh E. Schaffer11Hugo Lee12Thomas LaFramboise13Ilya Bederman14Peter Arvan15Clayton E. Mathews16Ivan C. Gerling17Klaus H. Kaestner18Boaz Tirosh19Feyza Engin20Maria Hatzoglou21Department of Genetics and Genome Sciences, Case Western Reserve UniversityDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityDepartment of Biochemistry, Case Western Reserve UniversityDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of MedicineDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityThe Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical CenterLerner Research Institute, Cleveland ClinicDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public HealthDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityThe Division of Metabolism, Endocrinology & Diabetes, University of Michigan Medical CenterDepartment of Pathology, Immunology and Laboratory Medicine, University of Florida College of MedicineDepartment of Medicine, University of TennesseeDepartment of Genetics and Institute for Diabetes, Obesity and Metabolism, University of Pennsylvania Perelman School of MedicineDepartment of Biochemistry, Case Western Reserve UniversityDepartment of Biomolecular Chemistry, University of Wisconsin-Madison, School of Medicine and Public HealthDepartment of Genetics and Genome Sciences, Case Western Reserve UniversityPancreatic β-cells are naturally prone to ER stress due to their role in insulin production and secretion. Here, the authors show that chronic ER stress adaptive exhaustion results in an irreversible loss of β-cell function leading to T1D pathogenesishttps://doi.org/10.1038/s41467-022-32425-7 |
| spellingShingle | Chien-Wen Chen Bo-Jhih Guan Mohammed R. Alzahrani Zhaofeng Gao Long Gao Syrena Bracey Jing Wu Cheikh A. Mbow Raul Jobava Leena Haataja Ajay H. Zalavadia Ashleigh E. Schaffer Hugo Lee Thomas LaFramboise Ilya Bederman Peter Arvan Clayton E. Mathews Ivan C. Gerling Klaus H. Kaestner Boaz Tirosh Feyza Engin Maria Hatzoglou Adaptation to chronic ER stress enforces pancreatic β-cell plasticity Nature Communications |
| title | Adaptation to chronic ER stress enforces pancreatic β-cell plasticity |
| title_full | Adaptation to chronic ER stress enforces pancreatic β-cell plasticity |
| title_fullStr | Adaptation to chronic ER stress enforces pancreatic β-cell plasticity |
| title_full_unstemmed | Adaptation to chronic ER stress enforces pancreatic β-cell plasticity |
| title_short | Adaptation to chronic ER stress enforces pancreatic β-cell plasticity |
| title_sort | adaptation to chronic er stress enforces pancreatic β cell plasticity |
| url | https://doi.org/10.1038/s41467-022-32425-7 |
| work_keys_str_mv | AT chienwenchen adaptationtochronicerstressenforcespancreaticbcellplasticity AT bojhihguan adaptationtochronicerstressenforcespancreaticbcellplasticity AT mohammedralzahrani adaptationtochronicerstressenforcespancreaticbcellplasticity AT zhaofenggao adaptationtochronicerstressenforcespancreaticbcellplasticity AT longgao adaptationtochronicerstressenforcespancreaticbcellplasticity AT syrenabracey adaptationtochronicerstressenforcespancreaticbcellplasticity AT jingwu adaptationtochronicerstressenforcespancreaticbcellplasticity AT cheikhambow adaptationtochronicerstressenforcespancreaticbcellplasticity AT rauljobava adaptationtochronicerstressenforcespancreaticbcellplasticity AT leenahaataja adaptationtochronicerstressenforcespancreaticbcellplasticity AT ajayhzalavadia adaptationtochronicerstressenforcespancreaticbcellplasticity AT ashleigheschaffer adaptationtochronicerstressenforcespancreaticbcellplasticity AT hugolee adaptationtochronicerstressenforcespancreaticbcellplasticity AT thomaslaframboise adaptationtochronicerstressenforcespancreaticbcellplasticity AT ilyabederman adaptationtochronicerstressenforcespancreaticbcellplasticity AT peterarvan adaptationtochronicerstressenforcespancreaticbcellplasticity AT claytonemathews adaptationtochronicerstressenforcespancreaticbcellplasticity AT ivancgerling adaptationtochronicerstressenforcespancreaticbcellplasticity AT klaushkaestner adaptationtochronicerstressenforcespancreaticbcellplasticity AT boaztirosh adaptationtochronicerstressenforcespancreaticbcellplasticity AT feyzaengin adaptationtochronicerstressenforcespancreaticbcellplasticity AT mariahatzoglou adaptationtochronicerstressenforcespancreaticbcellplasticity |