Positive Reciprocal Feedback of lncRNA ZEB1-AS1 and HIF-1α Contributes to Hypoxia-Promoted Tumorigenesis and Metastasis of Pancreatic Cancer

Positive Reciprocal Feedback of lncRNA ZEB1-AS1 and HIF-1α Contributes to Hypoxia-Promoted Tumorigenesis and Metastasis of Pancreatic Cancer

BackgroundMany studies have reported the roles of the extracellular hypoxia microenvironment in the tumorigenesis and metastasis of multiple cancers. However, long noncoding RNAs (lncRNAs) that induce cancer oncogenicity and metastasis of pancreatic cancer (PC) under hypoxia conditions remain unclea...

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Bibliographic Details
Main Authors: Yan Jin, Zhengming Zhang, Qiao Yu, Zhu Zeng, Hong Song, Xiaoxu Huang, Qi Kong, Hao Hu, Yabin Xia
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-11-01
Series:Frontiers in Oncology
Subjects:
pancreatic cancer
lncRNA-ZEB1-AS1
Zeb1
HIF-1α
metastasis
hypoxia
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2021.761979/full

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https://www.frontiersin.org/articles/10.3389/fonc.2021.761979/full

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