TNF-α Activating Osteoclasts in Patients with Psoriatic Arthritis Enhances the Recruitment of Osteoclast Precursors: A Plausible Role of WNT5A-MCP-1 in Osteoclast Engagement in Psoriatic Arthritis

TNF-α Activating Osteoclasts in Patients with Psoriatic Arthritis Enhances the Recruitment of Osteoclast Precursors: A Plausible Role of WNT5A-MCP-1 in Osteoclast Engagement in Psoriatic Arthritis

Psoriatic arthritis (PsA) results from joint destruction by osteoclasts. The promising efficacy of TNF-α blockage indicates its important role in osteoclastogenesis of PsA. WNT ligands actively regulate osteoclastogenesis. We investigated how WNT ligands activate osteoclasts amid the TNF-α milieu in...

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Bibliographic Details
Main Authors: Shang-Hung Lin, Ji-Chen Ho, Sung-Chou Li, Yu-Wen Cheng, Chung-Yuan Hsu, Wen-Yi Chou, Chang-Chun Hsiao, Chih-Hung Lee
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:International Journal of Molecular Sciences
Subjects:
psoriatic arthritis
TNF-α
osteoclastogenesis
WNT5A upregulation
MCP-1
osteoclast precursors
Online Access:https://www.mdpi.com/1422-0067/23/2/921

Internet

https://www.mdpi.com/1422-0067/23/2/921

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