Shikonin promotes hypertrophic scar repair by autophagy of hypertrophic scar-derived fibroblasts

ABSTRACT Purpose: To investigate the Shikonin (SHI) induce autophagy of hypertrophic scar-derived fibroblasts (HSFs) and the mechanism of which in repairing hypertrophic scar. Methods: This study showed that SHI induced autophagy from HSFs and repaired skin scars through the AMPK/mTOR pathway. Ala...

Full description

Bibliographic Details
Main Authors: Qing Zhang, Maomao Wang, Xingwang Deng, Dan Zhao, Fang Zhao, Jinli Xiao, Jiaxiang Ma, Xiaoliang Pan
Format: Article
Language:English
Published: Sociedade Brasileira para o Desenvolvimento da Pesquisa em Cirurgia 2023-10-01
Series:Acta Cirúrgica Brasileira
Subjects:
Online Access:http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0102-86502023000100237&lng=en&tlng=en