Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis

Brain pharmacokinetics of anti-transferrin receptor antibody affinity variants in rats determined using microdialysis

Receptor-mediated transcytosis (RMT) is used to enhance the delivery of monoclonal antibodies (mAb) into the central nervous system (CNS). While the binding to endogenous receptors on the brain capillary endothelial cells (BCECs) may facilitate the uptake of mAbs in the brain, a strong affinity for...

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Bibliographic Details
Main Authors: Hsueh-Yuan Chang, Shengjia Wu, Yingyi Li, Wanying Zhang, Matthew Burrell, Carl I. Webster, Dhaval K. Shah
Format: Article
Language:English
Published: Taylor & Francis Group 2021-01-01
Series:mAbs
Subjects:
Monoclonal Antibody (mAb)
brain Pharmacokinetics
large Pore Microdialysis
transferrin Receptor
receptor-Mediated Transcytosis (RMT)
brain Capillary Depletion
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2021.1874121

Internet

https://www.tandfonline.com/doi/10.1080/19420862.2021.1874121

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