Identifying lupus Patient Subsets Through Immune Cell Deconvolution of Gene Expression Data in Two Atacicept Phase II Studies

Identifying lupus Patient Subsets Through Immune Cell Deconvolution of Gene Expression Data in Two Atacicept Phase II Studies

Objective To use cell‐based gene signatures to identify patients with systemic lupus erythematous (SLE) in the phase II/III APRIL–SLE and phase IIb ADDRESS II trials most likely to respond to atacicept. Methods A published immune cell deconvolution algorithm based on Affymetrix gene array data was a...

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Bibliographic Details
Main Authors: Matthew Studham, Cristina Vazquez‐Mateo, Eileen Samy, Philipp Haselmayer, Aida Aydemir, P. Alexander Rolfe, Joan T. Merrill, Eric F. Morand, Julie DeMartino, Amy Kao, Robert Townsend
Format: Article
Language:English
Published: Wiley 2023-10-01
Series:ACR Open Rheumatology
Online Access:https://doi.org/10.1002/acr2.11594

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https://doi.org/10.1002/acr2.11594

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