Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage

Metal ion-responsive nanocarrier derived from phosphonated calix[4]arenes for delivering dauricine specifically to sites of brain injury in a mouse model of intracerebral hemorrhage

Abstract Primary intracerebral hemorrhage (ICH) is a leading cause of long-term disability and death worldwide. Drug delivery vehicles to treat ICH are less than satisfactory because of their short circulation lives, lack of specific targeting to the hemorrhagic site, and poor control of drug releas...

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Bibliographic Details
Main Authors: Mingxin Li, Guohao Liu, Kaixuan Wang, Lingfeng Wang, Xiang Fu, Lee Yong Lim, Wei Chen, Jingxin Mo
Format: Article
Language:English
Published: BMC 2020-04-01
Series:Journal of Nanobiotechnology
Subjects:
Intracerebral hemorrhage
Dauricine
Phosphonated calix[4]arene derivative
Targeted delivery
Apoptosis
Ferroptosis
Online Access:http://link.springer.com/article/10.1186/s12951-020-00616-3

Internet

http://link.springer.com/article/10.1186/s12951-020-00616-3

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