mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning

mGluR5 Is Substitutable for mGluR1 in Cerebellar Purkinje Cells for Motor Coordination, Developmental Synapse Elimination, and Motor Learning

Group I metabotropic glutamate receptors (mGluRs) include mGluR1 and mGluR5, which are coupled to the Gq family of heterotrimeric G-proteins and readily activated by their selective agonist 3,5-dihydroxyphenilglycine (DHPG). mGluR1 and mGluR5 exhibit nearly complementary distributions spatially or t...

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Bibliographic Details
Main Authors: Maria Harbers, Harumi Nakao, Takaki Watanabe, Kyoko Matsuyama, Shoichi Tohyama, Kazuki Nakao, Yasushi Kishimoto, Masanobu Kano, Atsu Aiba
Format: Article
Language:English
Published: MDPI AG 2022-06-01
Series:Cells
Subjects:
Purkinje cells
mGluR5
mGluR1
motor coordination
synapse elimination
eyeblink conditioning
Online Access:https://www.mdpi.com/2073-4409/11/13/2004

Internet

https://www.mdpi.com/2073-4409/11/13/2004

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