Polymorphic Molecular Signatures in Variable Regions of the <i>Plasmodium falciparum var2csa</i> DBL3x Domain Are Associated with Virulence in Placental Malaria

Polymorphic Molecular Signatures in Variable Regions of the <i>Plasmodium falciparum var2csa</i> DBL3x Domain Are Associated with Virulence in Placental Malaria

The <i>Plasmodium falciparum</i> protein VAR2CSA allows infected erythrocytes to accumulate within the placenta, inducing pathology and poor birth outcomes. Multiple exposures to placental malaria (PM) induce partial immunity against VAR2CSA, making it a promising vaccine candidate. Howe...

Full description

Bibliographic Details
Main Authors: Eldin Talundzic, Stephen Scott, Simon O. Owino, David S. Campo, Naomi W. Lucchi, Venkatachalam Udhayakumar, Julie M. Moore, David S. Peterson
Format: Article
Language:English
Published: MDPI AG 2022-04-01
Series:Pathogens
Subjects:
placental malaria
VAR2CSA
chondroitin sulfate A
polymorphism
low birth weight
chronic infection
Online Access:https://www.mdpi.com/2076-0817/11/5/520

Internet

https://www.mdpi.com/2076-0817/11/5/520

Similar Items