Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages

Untargeted metabolomics analysis reveals Mycobacterium tuberculosis strain H37Rv specifically induces tryptophan metabolism in human macrophages

Abstract Background Tuberculosis (TB) caused by Mycobacterium tuberculosis (M. tb) remains a global health issue. The characterized virulent M. tb H37Rv, avirulent M. tb H37Ra and BCG strains are widely used as reference strains to investigate the mechanism of TB pathogenicity. Here, we attempted to...

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Bibliographic Details
Main Authors: Guohui Xiao, Su Zhang, Like Zhang, Shuyan Liu, Guobao Li, Min Ou, Xuan Zeng, Zhaoqin Wang, Guoliang Zhang, Shuihua Lu
Format: Article
Language:English
Published: BMC 2022-10-01
Series:BMC Microbiology
Subjects:
mycobacterium tuberculosis
Metabolome
THP-1
Tryptophan metabolism
Virulence
Online Access:https://doi.org/10.1186/s12866-022-02659-y

Internet

https://doi.org/10.1186/s12866-022-02659-y

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