Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System

Targeted Mutation (R100W) of the Gene Encoding NGF Leads to Deficits in the Peripheral Sensory Nervous System

Nerve growth factor (NGF) exerts multifaceted functions through different stages of life. A missense mutation (R100W) in the beta-NGF gene was found in hereditary sensory autonomic neuropathy V (HSAN V) patients with severe loss of pain perception but without overt cognitive impairment. To better un...

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Bibliographic Details
Main Authors: Wanlin Yang, Kijung Sung, Fengli Zhou, Wei Xu, Robert A. Rissman, Jianqing Ding, Chengbiao Wu
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-11-01
Series:Frontiers in Aging Neuroscience
Subjects:
hereditary sensory autonomic neuropathy V
nerve growth factor
TrkA
p75 neurotrophic factor receptor
Intraepidermal Nerve Fiber
Online Access:https://www.frontiersin.org/article/10.3389/fnagi.2018.00373/full

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https://www.frontiersin.org/article/10.3389/fnagi.2018.00373/full

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