Divergent CD4+ T-cell profiles are associated with anti-HLA alloimmunization status in platelet-transfused AML patients

Divergent CD4+ T-cell profiles are associated with anti-HLA alloimmunization status in platelet-transfused AML patients

IntroductionAcute myeloid leukemia (AML) is one of the commonest hematologic disorders. Due to the high frequency of disease- or treatment-related thrombocytopenia, AML requires treatment with multiple platelet transfusions, which can trigger a humoral response directed against platelets. Some, but...

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Bibliographic Details
Main Authors: Mehdi Khelfa, Mathieu Leclerc, Stéphane Kerbrat, Yakout Nait Sidenas Boudjemai, Médine Benchouaia, Déborah Neyrinck-Leglantier, Léonie Cagnet, Lylia Berradhia, Marie Tamagne, Laure Croisille, France Pirenne, Sébastien Maury, Benoît Vingert
Format: Article
Language:English
Published: Frontiers Media S.A. 2023-08-01
Series:Frontiers in Immunology
Subjects:
acute myeloid leukemia
alloimmunization
multi-omics
CD4+ T lymphocytes
platelet transfusion
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165973/full

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https://www.frontiersin.org/articles/10.3389/fimmu.2023.1165973/full

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