Pancreatic acinar cell fate relies on system xC - to prevent ferroptosis during stress

Pancreatic acinar cell fate relies on system xC - to prevent ferroptosis during stress

Abstract Acinar cell dedifferentiation is one of the most notable features of acute and chronic pancreatitis. It can also be the initial step that facilitates pancreatic cancer development. In the present study, we further decipher the precise mechanisms and regulation using primary human cells and...

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Bibliographic Details
Main Authors: Zhaolong Pan, Jan-Lars Van den Bossche, Eva Rodriguez-Aznar, Pauline Janssen, Olaya Lara, Gamze Ates, Ann Massie, Diedert Luc De Paep, Isabelle Houbracken, Marco Mambretti, Ilse Rooman
Format: Article
Language:English
Published: Nature Publishing Group 2023-08-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-023-06063-w

Internet

https://doi.org/10.1038/s41419-023-06063-w

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