Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models

Peripheral injections of melanin-concentrating hormone receptor 1 antagonist S38151 decrease food intake and body weight in rodent obesity models

The compound S38151 is a nanomolar antagonist that acts at the melanin-concentrating hormone receptor 1 (MCH1). S38151 is more stable than its purely peptide counterpart, essentially because of the blockade of its N-terminus. Therefore, , its action on various models of obesity was studied. Acute in...

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Bibliographic Details
Main Authors: Odile eDella-Zuana, Valerie eAudinot, Viviane eLevenez, Alain eKtorza, Françoise ePresse, Jean-Louis eNahon, Jean Albert Boutin
Format: Article
Language:English
Published: Frontiers Media S.A. 2012-12-01
Series:Frontiers in Endocrinology
Subjects:
Feeding Behavior
Mice
rat
receptors
melanin-concentrating hormone
peptide antagonists
Online Access:http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00160/full

Internet

http://journal.frontiersin.org/Journal/10.3389/fendo.2012.00160/full

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