Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

Hypothalamic-specific manipulation of Fto, the ortholog of the human obesity gene FTO, affects food intake in rats.

Sequence variants in the first intron of FTO are strongly associated with human obesity and human carriers of the risk alleles show evidence for increased appetite and food intake. Mice globally lacking Fto display a complex phenotype characterised by both increased energy expenditure and increased...

Full description

Bibliographic Details
Main Authors: Yi-Chun Loraine Tung, Eduard Ayuso, Xiaoye Shan, Fatima Bosch, Stephen O'Rahilly, Anthony P Coll, Giles S H Yeo
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2010-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC2808248?pdf=render

Internet

http://europepmc.org/articles/PMC2808248?pdf=render

Similar Items