KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model

KLF5 protects the intestinal epithelium against Th17 immune response in a murine colitis model

Inflammatory bowel disease (IBD) is a chronic illness characterized by dysregulated immune cascades in the intestines, in which the Th17 immune response plays an important role. We demonstrated that mice with intestinal epithelium–specific deletion of Krüppel-like factor 5 (Klf5) developed Th17-depe...

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Bibliographic Details
Main Authors: Jason Shieh, Timothy H. Chu, Yang Liu, Julie Kim, Ainara Ruiz de Sabando, Soma Kobayashi, Sui Y. Zee, Brian S. Sheridan, Agnieszka B. Bialkowska, Vincent W. Yang
Format: Article
Language:English
Published: American Society for Clinical investigation 2022-04-01
Series:JCI Insight
Subjects:
Gastroenterology
Inflammation
Online Access:https://doi.org/10.1172/jci.insight.153488

Internet

https://doi.org/10.1172/jci.insight.153488

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