Optogenetics-induced activation of glutamate receptors improves memory function in mice with Alzheimer’s disease

Optogenetics-induced activation of glutamate receptors improves memory function in mice with Alzheimer’s disease

Optogenetics is a combination of optics and genetics technology that can be used to activate or inhibit specific cells in tissues. It has been used to treat Parkinson’s disease, epilepsy and neurological diseases, but rarely Alzheimer’s disease. Adeno-associated virus carrying the CaMK promoter driv...

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Bibliographic Details
Main Authors: Ke-Wei Wang, Xiao-Lin Ye, Ting Huang, Xi-Fei Yang, Liang-Yu Zou
Format: Article
Language:English
Published: Wolters Kluwer Medknow Publications 2019-01-01
Series:Neural Regeneration Research
Subjects:
nerve regeneration; Alzheimer′s disease; amyloid-β1–42; dentate gyrus; channelrhodopsin-2; glutamate receptors; memory; neuroinflammation; novel object recognition; immunohistochemistry; western blot assay; neural regeneration
Online Access:http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=12;spage=2147;epage=2155;aulast=Wang

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http://www.nrronline.org/article.asp?issn=1673-5374;year=2019;volume=14;issue=12;spage=2147;epage=2155;aulast=Wang

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