Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress

Impact of Metformin Treatment on Human Placental Energy Production and Oxidative Stress

Metformin is increasingly prescribed in pregnancy, with beneficial maternal effects. However, it is not known how metformin-treatment impacts metabolism and energy production in the developing feto-placental unit. We assessed the human placental response to metformin using both in vivo and in vitro...

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Bibliographic Details
Main Authors: Jane L. Tarry-Adkins, India G. Robinson, Rebecca M. Reynolds, Irving L. M. H. Aye, D. Stephen Charnock-Jones, Benjamin Jenkins, Albert Koulmann, Susan E. Ozanne, Catherine E. Aiken
Format: Article
Language:English
Published: Frontiers Media S.A. 2022-06-01
Series:Frontiers in Cell and Developmental Biology
Subjects:
placenta
metformin
trophoblast
oxidative stress
mitochondria
respiration
Online Access:https://www.frontiersin.org/articles/10.3389/fcell.2022.935403/full

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https://www.frontiersin.org/articles/10.3389/fcell.2022.935403/full

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