Protective Effect of Val129-PrP against Bovine Spongiform Encephalopathy but not Variant Creutzfeldt-Jakob Disease

Protective Effect of Val129-PrP against Bovine Spongiform Encephalopathy but not Variant Creutzfeldt-Jakob Disease

Bovine spongiform encephalopathy (BSE) is the only known zoonotic prion that causes variant Creutzfeldt-Jakob disease (vCJD) in humans. The major risk determinant for this disease is the polymorphic codon 129 of the human prion protein (Hu-PrP), where either methionine (Met129) or valine (Val129) ca...

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Bibliographic Details
Main Authors: Natalia Fernández-Borges, Juan Carlos Espinosa, Alba Marín-Moreno, Patricia Aguilar-Calvo, Emmanuel A. Asante, Tetsuyuki Kitamoto, Shirou Mohri, Olivier Andréoletti, Juan María Torres
Format: Article
Language:English
Published: Centers for Disease Control and Prevention 2017-09-01
Series:Emerging Infectious Diseases
Subjects:
Bovine spongiform encephalopathy
BSE
prion susceptibility
PrP
Val129-PrP
transmission barrier
Online Access:https://wwwnc.cdc.gov/eid/article/23/9/16-1948_article

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https://wwwnc.cdc.gov/eid/article/23/9/16-1948_article

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