Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation

Harnessing whole human liver ex situ normothermic perfusion for preclinical AAV vector evaluation

Abstract Developing clinically predictive model systems for evaluating gene transfer and gene editing technologies has become increasingly important in the era of personalized medicine. Liver-directed gene therapies present a unique challenge due to the complexity of the human liver. In this work, w...

Full description

Bibliographic Details
Main Authors: Marti Cabanes-Creus, Sophia H. Y. Liao, Renina Gale Navarro, Maddison Knight, Deborah Nazareth, Ngee-Soon Lau, Mark Ly, Erhua Zhu, Ramon Roca-Pinilla, Ricardo Bugallo Delgado, Ana F. Vicente, Grober Baltazar, Adrian Westhaus, Jessica Merjane, Michael Crawford, Geoffrey W. McCaughan, Carmen Unzu, Gloria González-Aseguinolaza, Ian E. Alexander, Carlo Pulitano, Leszek Lisowski
Format: Article
Language:English
Published: Nature Portfolio 2024-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-46194-y

Internet

https://doi.org/10.1038/s41467-024-46194-y

Similar Items