Identification of 11-Hydroxytephrosin and Torosaflavone A as Potential Inhibitors of 3-Phosphoinositide-Dependent Protein Kinase 1 (PDPK1): Toward Anticancer Drug Discovery

Identification of 11-Hydroxytephrosin and Torosaflavone A as Potential Inhibitors of 3-Phosphoinositide-Dependent Protein Kinase 1 (PDPK1): Toward Anticancer Drug Discovery

The 3-phosphoinositide-dependent protein kinase 1 (PDPK1) has a significant role in cancer progression and metastasis as well as other inflammatory disorders, and has been proposed as a promising therapeutic target for several malignancies. In this work, we conducted a systematic virtual screening o...

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Bibliographic Details
Main Authors: Akhtar Atiya, Fahad A. Alhumaydhi, Sharaf E. Sharaf, Waleed Al Abdulmonem, Abdelbaset Mohamed Elasbali, Maher M. Al Enazi, Anas Shamsi, Talha Jawaid, Badrah S. Alghamdi, Anwar M. Hashem, Ghulam Md. Ashraf, Moyad Shahwan
Format: Article
Language:English
Published: MDPI AG 2022-08-01
Series:Biology
Subjects:
3-phosphoinositide-dependent protein kinase 1
cancer
Indian phytoconstituents
drug discovery
virtual screening
conformational dynamics
Online Access:https://www.mdpi.com/2079-7737/11/8/1230

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https://www.mdpi.com/2079-7737/11/8/1230

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