Differential effects of interleukin-17A and 17F on cell interactions between immune cells and stromal cells from synovium or skin

Abstract We compared the contribution of IL-17A and IL-17F in co-culture systems mimicking cell interactions as found in inflamed synovium and skin. Synoviocytes or skin fibroblasts were co-cultured with activated PBMC, with IL-17A, IL-17 A/F, IL-17F, IL-23, anti-IL-17A, anti-IL-17A/F or anti-IL-17F...

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Bibliographic Details
Main Authors: Issam Tout, Mélissa Noack, Pierre Miossec
Format: Article
Language:English
Published: Nature Portfolio 2023-11-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-023-45653-8