Cryo-EM structures of orphan GPR21 signaling complexes

Cryo-EM structures of orphan GPR21 signaling complexes

In this work, the authors report Cryo-EM structures of the signaling complexes of human GPR21, an orphan GPCR and a potential metabolic disease target, and reveal unique receptor activation conformation when bound to downstream signaling proteins in the absence of any ligand.

Bibliographic Details
Main Authors: Xi Lin, Bo Chen, Yiran Wu, Yingqi Han, Ao Qi, Junyan Wang, Zhao Yang, Xiaohu Wei, Tingting Zhao, Lijie Wu, Xin Xie, Jinpeng Sun, Jie Zheng, Suwen Zhao, Fei Xu
Format: Article
Language:English
Published: Nature Portfolio 2023-01-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-023-35882-w

Internet

https://doi.org/10.1038/s41467-023-35882-w

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